Legal Protection is any effort made consciously by everyone and government, and private institutions. Nurses in hospitals are an important concern, one of which is in receiving occupational safety law protection when carrying out their work at the hospital because the work they do is at high risk of work accidents and consequent diseases. This study aims to analyze the Legal Protection Against Health and Safety (K3), Nurses In The Emergency Room Room. This type of research is qualitative research and descriptive. The research location of Royal Prima Hospital Medan from February to April 2022 with a total sample of 9 people. The data analysis used is qualitative descriptive analysis research. The results of occupational safety management (SMK3) have been made based on the rules of the occupational safety management system (SMK3) government regulation No. 50 of 2012. Royal Prima Hospital has complied with Government Regulation Number 14 of 1993 concerning the implementation of the workforce social guarantee system contained in article 2 concerning social security for workers. Royal Prima Hospital complies with the provisions of occupational safety law No. 1 of 1970, regulating work safety in all workplaces, be it land, sea, and air within the territory of the Republic of Indonesia. In conclusion, Royal Prima Hospital Medan very much maintains the health and safety of its workforce, especially nurses as one of the medical personnel in the field of services at the forefront.