Unlike the world’s oldest federation which exists in USA, India’s federalism is quite unique and different therefrom. Presently, several nations are trying to find out the suitable governmental system whether unitary or federal, which will effective to combat the deadly coronavirus outbreak. The Indian Prime Minister held six interactive sessions with the respective Chief Ministers of States in between the last two peaks of covid-19 waves i.e., September’ 2020 to April’ 2021 with objective to manage covid-19 infections as highly raised in certain States/UTs. So, this paper aims to find out various difficulties faced by Indian federal structure while managing the covid-19 pandemic; to highlight relevant Indian legal provisions which may promote corelation between Central and States governments; to discuss the Supreme Court’s decisions in connection with resolving deadlock thereat. Thus, efficacy and effectiveness of co-operative federal structure has been critically analysed hereby in special reference to covid-19 a ‘notified disaster’ in India also with a futuristic approach.