Infection Prevention and Control (PPI) is included in the standard group of Hospital management so that a good PPI organizing system can improve the quality of hospital services. The purpose of infection prevention and control programs in hospitals is to identify and reduce the risk of infection transmission or transmission among patients, staff, health professionals, contract workers, volunteers, students, and visitors. This study aims to examine the Legal Basis for Evaluating the Implementation of the Infection Control Planning and Prevention Program (PPI) at Royal Prima Hospital Medan. The method used in this study is a qualitative analysis method. The location of the study was conducted at RSU Royal Prima Medan, and the time of this study was between February – March 2022. Data analysis was carried out by Triangulation Test by finding facts during surveys and observations. From the in-depth interview, it was found that in terms of fulfilling facilities and budgeting PPI, the RS leadership strongly supports the program. Integrated management support is budget and human resources in the form of providing budgets or funds for education and training activities outside the hospital to form a PPI Team. Regular socialization is carried out at regular employee meetings at the end of each month and at the time of orientation of new employees. In conclusion, Royal Prima Hospital Medan has implemented an Infection Prevention and Control System (PPI) in hospitals based on the Regulation of the Minister of Health of the Republic of Indonesia Number 27 of 2017, and is running well.